| 中文名称Chinese name
|
SARS-CoV-2 nCoV-WA1-2020 气管，滴鼻，口腔，眼途径联合感染猕猴模型 |
| 编号Model number |
|
| 英文名称English name |
SARS-CoV-2 nCoV-WA1-2020 intratracheally, intranasally, orally, ocularly infection rhesus macaques mouse model |
| 物种Species name |
|
| 品系Strain name |
|
| 人类疾病Human diseases |
COVID-19 |
| 传染性Infectivity |
是 |
| 微生物Microorganism |
|
| 类别Category |
新型冠状病毒动物模型 |
| 造模因素Modeling factors |
|
| 制作方法Making method |
NHPs - 9 adult rhesus macaques (8M, 1F) were randomly divided into two groups of six and three animals. Group 1 was vaccinated with ChAdOx1 nCoV-19 at -28 DPI, group 2 was vaccinated with ChAdOx1 GFP at -28 DPI. All vaccinations were done with 2.5*10**10｜VP/animal diluted in sterile PBS. Blood samples were obtained before vaccination and 14 days thereafter. Animals were challenged with SARS-CoV-2 strain nCoV-WA1-2020 (MN985325.1) diluted in sterile DMEM on 0 DPI; with administration of 4 mL intratracheally, 1 mL intranasally, 1 mL orally and 0.5 mL ocularly of 4*10**5 TCID50/mL virus suspension. |
| 生物学特征Biological characteristics |
|
| 医学用途Medical use |
#REF! |
| 临床表现Clinical manifestation |
|
| 病理表现Pathology |
|
| 发病天数Days of onset |
|
| 发病过程Pathogenesis process |
|
| 临床诊断Clinical diagnosis |
肺炎 |
| 评价模型成功的指标Indicators for evaluating model success |
|
| 保藏单位Preservation unit |
落基山实验室@@https://www.niaid.nih.gov/ |
| 参考文献Reference |
ChAdOx1 nCoV-19 vaccination prevents SARS-CoV-2 pneumonia in rhesus macaques,PMID:32511340,DOI:10.1101/2020.05.13.093195 |
| 录入/更新时间Date |
2021.7.20 |
| 备注Remarks |
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