| 中文名称Chinese name
|
HIV SHIV-SF162P3 直肠途径感染中国猕猴模型 |
| 编号Model number |
|
| 英文名称English name |
HIV SHIV-SF162P3 intrarectally infected Chinese rhesus macaques model |
| 物种Species name |
猴
|
| 品系Strain name |
|
| 人类疾病Human diseases |
HIV |
| 传染性Infectivity |
是 |
| 微生物Microorganism |
|
| 类别Category |
HIV感染动物模型 |
| 造模因素Modeling factors |
|
| 制作方法Making method |
Eight Chinese-origin rhesus macaques were inoculated intrarectally with 3 × 10^6 TCID50 (50% tissue culture infective dose) SHIV-SF162P3 on day 0. Beginning on week 8 after infection, each macaque
received ART (3TC/50 mg/kg/once daily + LPV/r/15 mg/kg/twice daily).During ART, macaques were vaccinated by the intramuscular route with three vaccinations with DNA vaccine expressing HIV-1CN54-gp140 and SIVMac239-gag at weeks15, 19 and 22. At week 26, a booster vaccination was given by intradermal route with replication-competent recombinant Tiantan vaccinia virus expressing HIV-1CN54 gag, pol and env -gp140 genes (rTVgpe) and SIV Mac239-gag. |
| 生物学特征Biological characteristics |
|
| 医学用途Medical use |
用于HIV致病机制研究、疫苗和药物评估。 |
| 临床表现Clinical manifestation |
|
| 病理表现Pathology |
|
| 发病天数Days of onset |
|
| 发病过程Pathogenesis process |
|
| 临床诊断Clinical diagnosis |
|
| 评价模型成功的指标Indicators for evaluating model success |
|
| 保藏单位Preservation unit |
北京大学医学部@@http://www.bjmu.edu.cn/ |
| 参考文献Reference |
CTL-mediated immunotherapy can suppress SHIV rebound in ART-free macaques.,PMID:31113957,DOI:10.1038/s41467-019-09725-6 |
| 录入/更新时间Date |
2021.7.20 |
| 备注Remarks |
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