| 中文名称Chinese name
|
HIV-1 JR-CSF气管途径感染TKO-BLT小鼠模型 |
| 编号Model number |
|
| 英文名称English name |
HIV-1 JR-CSF intrarectally infected TKO-BLT mouse model |
| 物种Species name |
小鼠
|
| 品系Strain name |
|
| 人类疾病Human diseases |
HIV |
| 传染性Infectivity |
是 |
| 微生物Microorganism |
|
| 类别Category |
HIV感染动物模型 |
| 造模因素Modeling factors |
|
| 制作方法Making method |
Developing a BLT model on the C57BL/6 background C57BL/6 Rag22/2gc2/2 mice have been described previously.23-25 CD47-null B6.129-CD47tm1Fpl/J mice (The Jackson Laboratory, Bar Harbor,ME) were crossed with C57BL/6 Rag22/2gc2/2 females, and F1 Rag21/2gc-/Y CD471/2 males were backcrossed with Rag22/2gc2/2 females. Mating of F2 Rag22/2gc2/2CD471/2 females and Rag22/2gc -/YCD471/2 males produced
theRag22/2gc2/2CD472/2 (TKO) strain.Forty-eight TKO-BLT mice were inoculated intrarectally with 10^5 TCIU of HIVJR-CSF. Twenty-six (54%) of the mice became infected with p24 plasma titers peaking between 2 and 4 weeks postinfection (wpi) and then declining over the next several weeks. |
| 生物学特征Biological characteristics |
|
| 医学用途Medical use |
用于HIV致病机制研究、疫苗和药物评估。 |
| 临床表现Clinical manifestation |
|
| 病理表现Pathology |
|
| 发病天数Days of onset |
|
| 发病过程Pathogenesis process |
|
| 临床诊断Clinical diagnosis |
|
| 评价模型成功的指标Indicators for evaluating model success |
|
| 保藏单位Preservation unit |
落基山实验室@@https://www.niaid.nih.gov/about/rocky-mountain-laboratories |
| 参考文献Reference |
BLT-humanized C57BL/6 Rag2-/-γc-/-CD47-/- mice are resistant to GVHD and develop B- and T-cell immunity to HIV infection,PMID:24021673,DOI:10.1182/blood-2013-06-506949 |
| 录入/更新时间Date |
2021.7.20 |
| 备注Remarks |
|
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