| 中文名称Chinese name
|
SARS-CoV Urbani滴鼻感染C57BL/6J小鼠模型 |
| 编号Model number |
|
| 英文名称English name |
SARS-CoV Urbani intranasally infection C57BL/6J mouse model |
| 物种Species name |
小鼠
|
| 品系Strain name |
C57BL/6J小鼠
|
| 人类疾病Human diseases |
SARS |
| 传染性Infectivity |
是 |
| 微生物Microorganism |
|
| 类别Category |
SARS-CoV感染动物模型 |
| 造模因素Modeling factors |
|
| 制作方法Making method |
SARS-CoV causes lethal disease in K18-hACE2 mice. K18-hACE2 mice (lines 1 [n=15], 2 [n=11], and 3 [n=15])and 15 non-Tg mice were infected intranasally with 2.3×10^4 PFU of SARS-CoV and were monitored daily for mortality. |
| 生物学特征Biological characteristics |
|
| 医学用途Medical use |
用于SARS-CoV致病机制研究、疫苗和药物评估。 |
| 临床表现Clinical manifestation |
|
| 病理表现Pathology |
|
| 发病天数Days of onset |
|
| 发病过程Pathogenesis process |
|
| 临床诊断Clinical diagnosis |
支气管周炎症 |
| 评价模型成功的指标Indicators for evaluating model success |
|
| 保藏单位Preservation unit |
爱荷华大学@@https://uiowa.edu/ |
| 参考文献Reference |
Lethal Infection of K18-hACE2 Mice Infected with Severe Acute Respiratory Syndrome Coronavirus,PMID:17079315,DOI:10.1128/JVI.02012-06 |
| 录入/更新时间Date |
2021.7.20 |
| 备注Remarks |
|
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