| 中文名称Chinese name
|
SARS-CoV Urbani滴鼻感染BALB/c小鼠模型 |
| 编号Model number |
|
| 英文名称English name |
SARS-CoV Urbani intranasally infection BALB/c mouse model |
| 物种Species name |
小鼠
|
| 品系Strain name |
BALB/c小鼠
|
| 人类疾病Human diseases |
SARS |
| 传染性Infectivity |
是 |
| 微生物Microorganism |
|
| 类别Category |
SARS-CoV感染动物模型 |
| 造模因素Modeling factors |
|
| 制作方法Making method |
T cells from vaccinated (immune) or nonimmune (control) mice were enriched using a Pan T-Cell Isolation Kit (Miltenyi Biotec). Approximately 3×10^7 T cells in 0.5 ml PBS were administered into each recipient naive BALB/c mouse intravenously through the tail vein 24 h before challenge. |
| 生物学特征Biological characteristics |
|
| 医学用途Medical use |
用于SARS-CoV致病机制研究、疫苗和药物评估。 |
| 临床表现Clinical manifestation |
|
| 病理表现Pathology |
|
| 发病天数Days of onset |
|
| 发病过程Pathogenesis process |
|
| 临床诊断Clinical diagnosis |
|
| 评价模型成功的指标Indicators for evaluating model success |
|
| 保藏单位Preservation unit |
美国国家过敏和传染病研究所疫苗研究中心@@https://www.niaid.nih.gov/about/vrc |
| 参考文献Reference |
A DNA vaccine induces SARS coronavirus neutralization and protective immunity in mice.,PMID:15024391,DOI:10.1038/nature02463 |
| 录入/更新时间Date |
2021.7.20 |
| 备注Remarks |
|
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