| 中文名称Chinese name
|
SHIV SF162P3静脉途径感染猕猴模型 |
| 编号Model number |
|
| 英文名称English name |
SHIV SF162P3 intravenously infected rhesus monkey model |
| 物种Species name |
猴
|
| 品系Strain name |
|
| 人类疾病Human diseases |
HIV |
| 传染性Infectivity |
是 |
| 微生物Microorganism |
|
| 类别Category |
HIV感染动物模型 |
| 造模因素Modeling factors |
|
| 制作方法Making method |
Five rhesus monkeys (J1-J5) were intravenously infected with SHIVSF162P3 over 3 months, when chronic infection had been established with set-point viral loads of 3.11-4.84 log10 RNA copies/ml. Then, the monkeys were subcutaneously treated by LP-51 at 1 mg/kg once daily for 4 weeks. |
| 生物学特征Biological characteristics |
|
| 医学用途Medical use |
用于HIV致病机制研究、疫苗和药物评估。 |
| 临床表现Clinical manifestation |
|
| 病理表现Pathology |
|
| 发病天数Days of onset |
|
| 发病过程Pathogenesis process |
|
| 临床诊断Clinical diagnosis |
病毒在血液中复制 |
| 评价模型成功的指标Indicators for evaluating model success |
|
| 保藏单位Preservation unit |
北京协和医学院@@http://english.cams.cn/index.html |
| 参考文献Reference |
Design of Novel HIV-1/2 Fusion Inhibitors with High Therapeutic Efficacy in Rhesus Monkey Models.,PMID:29899103,DOI:10.1128/JVI.00775-18 |
| 录入/更新时间Date |
2021.7.20 |
| 备注Remarks |
|
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