| 中文名称Chinese name
|
HIV-1 JRCSF腹腔途径感染NSG小鼠模型 |
| 编号Model number |
|
| 英文名称English name |
HIV-1 JRCSF intraperitoneally infected NSG mouse model |
| 物种Species name |
小鼠
|
| 品系Strain name |
|
| 人类疾病Human diseases |
HIV |
| 传染性Infectivity |
是 |
| 微生物Microorganism |
|
| 类别Category |
HIV感染动物模型 |
| 造模因素Modeling factors |
|
| 制作方法Making method |
We transplanted 2 9 105 freshly isolated CD34+ cells into mice by intravenous tail injection within 16–24 hr of a second busulfan injection. After 130–150 days of CB-HPC transplantation, nine groups of mice (n = 70) (Table 1) were inoculated with HIV- 1JRCSF (5000 TCID50) by intraperitoneal route. Group 5, 6, 7 and 8 mice were treated with minocycline at a dose of 100 mg/kg/day by intraperitoneal injection. Six mice of group 9 were used to measure the basal level of cytokines and LPS in the plasma samples. |
| 生物学特征Biological characteristics |
|
| 医学用途Medical use |
用于HIV致病机制研究、疫苗和药物评估。 |
| 临床表现Clinical manifestation |
|
| 病理表现Pathology |
|
| 发病天数Days of onset |
|
| 发病过程Pathogenesis process |
|
| 临床诊断Clinical diagnosis |
病毒在血液中复制 |
| 评价模型成功的指标Indicators for evaluating model success |
|
| 保藏单位Preservation unit |
比利时列日大学@@https://www.uliege.be/cms/c_8699436/fr/uliege |
| 参考文献Reference |
Minocycline attenuates HIV-1 infection and suppresses chronic immune activation in humanized NOD/LtsZ-scidIL-2Rγ(null) mice,PMID:24409837,DOI:10.1111/imm.12246 |
| 录入/更新时间Date |
2021.7.20 |
| 备注Remarks |
|
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