| 中文名称Chinese name
|
HIV HIV-1 腹腔途径感染Hu-NSG小鼠 模型 |
| 编号Model number |
|
| 英文名称English name |
HIV HIV-1 intraperitoneally infected Hu-NSG mice model |
| 物种Species name |
小鼠
|
| 品系Strain name |
|
| 人类疾病Human diseases |
HIV |
| 传染性Infectivity |
是 |
| 微生物Microorganism |
|
| 类别Category |
HIV感染动物模型 |
| 造模因素Modeling factors |
|
| 制作方法Making method |
new born NSG mice were irradiated with a sub-lethal dose of radiation (1 Gy) using a RS‐2000 X‐Ray Irradiator (Rad Source Technologies). CD34+ Hu-NSG were enriched from human cord blood using immune-magnetic beads (CD34+ selection kit; Miltenyi Biotec Inc., Auburn, CA, USA). CD34+ cell purity was >90% as confirmed by flow cytometry and then injected intra-hepatically (IH) at 50,000 cells/ mouse. Each donor derived cells were used to reconstitute from 2 to 10 mice depending on the sample size and yield. |
| 生物学特征Biological characteristics |
|
| 医学用途Medical use |
用于HIV致病机制研究、疫苗和药物评估。 |
| 临床表现Clinical manifestation |
|
| 病理表现Pathology |
|
| 发病天数Days of onset |
|
| 发病过程Pathogenesis process |
|
| 临床诊断Clinical diagnosis |
|
| 评价模型成功的指标Indicators for evaluating model success |
|
| 保藏单位Preservation unit |
內布拉斯加大学医学中心@@https://www.unmc.edu |
| 参考文献Reference |
HIV-1-Associated Left Ventricular Cardiac Dysfunction in Humanized Mice,PMID:32546795,DOI:10.1038/s41598-020-65943-9 |
| 录入/更新时间Date |
2021.7.20 |
| 备注Remarks |
|
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