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Age-related rhesus macaque models of COVID-19
摘要：
background: Since December 2019, an outbreak of the Corona Virus disease 2019(COVID-19) caused by severe acute respiratory syndrome coronavirus (SARS-CoV-2) in Wuhan, China, has become a public health emergency of international concern. The high fatality of aged cases caused by SARS-CoV-2 was a need to explore the possible age-related phenomena with non-human primate models.
Methods: Three 3-5 years old and two 15 years old rhesus macaques were intratracheally infected with SARS-CoV-2, and then analyzed by clinical signs, viral replication,chest X-ray, histopathological changes and immune response.
Results: Viral replication of nasopharyngeal swabs, anal swabs and lung in old monkeys was more active than that in young monkeys for 14 days after SARS-CoV-2 challenge. Monkeys developed typical interstitial pneumonia characterized by thickened alveolar septum accompanied with inflammation and edema, notably, old monkeys exhibited diffuse severe interstitial pneumonia. Viral antigens were detected mainly in alveolar epithelial cells and macrophages.
Conclusion: SARS-CoV-2 caused more severe interstitial pneumonia in old monkeys than that in young monkeys. Rhesus macaque models infected with SARS-CoV-2
作者：Pin Yu, Feifei Qi, Yanfeng Xu, Fengdi Li, Peipei Liu, Jiayi Liu, Linlin Bao, Wei Deng, Hong Gao, Zhiguang Xiang, Chong Xiao, Qi Lv, Shuran Gong, Jiangning Liu, Zhiqi Song, Yajin Qu, Jing Xue, Qiang Wei, Mingya Liu, Guanpeng Wang, Shunyi Wang, Haisheng Yu, Xing Liu, Baoying Huang, Wenling Wang, Li Zhao, Huijuan Wang, Fei Ye, Weimin Zhou, Wei Zhen, Jun Han, Guizhen Wu, Qi Jin, Jianwei Wang, Wenjie Tan, Chuan Qin
关键词：pathogenicity, pneumonia, rhesus macaque model, SARS-CoV-2
发表日期：2020年3月12日
原文链接：https://onlinelibrary.wiley.com/doi/full/10.1002/ame2.12108
