| 中文名称Chinese name
|
SARS-CoV-2 USA-WA1/2020 滴鼻感染叙利亚仓鼠模型 |
| 编号Model number |
|
| 英文名称English name |
SARS-CoV-2 USA-WA1/2020 intranasally infection Syrian hamsters model |
| 物种Species name |
仓鼠
|
| 品系Strain name |
叙利亚仓鼠
|
| 人类疾病Human diseases |
COVID-19 |
| 传染性Infectivity |
是 |
| 微生物Microorganism |
|
| 类别Category |
新型冠状病毒动物模型 |
| 造模因素Modeling factors |
|
| 制作方法Making method |
SARS-CoV-2-specific human neutralizing mAb CC12.1 isolated from natural infection was injected intraperitoneally into Syrian hamsters at a starting dose of 2 mg/animal (on average 16.5 mg/kg) and subsequent serial 4-fold dilutions. Control animals received 2 mg of a dengue-specific human IgG1 (Den3). Each group of 6 animals were challenged intranasally 12h post-infusion with 1X106 PFU of SARS-CoV-2. |
| 生物学特征Biological characteristics |
|
| 医学用途Medical use |
用于新冠肺炎COVID-19致病机制研究、疫苗和药物评估。 |
| 临床表现Clinical manifestation |
|
| 病理表现Pathology |
|
| 发病天数Days of onset |
|
| 发病过程Pathogenesis process |
|
| 临床诊断Clinical diagnosis |
|
| 评价模型成功的指标Indicators for evaluating model success |
|
| 保藏单位Preservation unit |
斯克里普斯研究所@@https://www.scripps.edu/science-and-medicine/research-departments/immunology-and-microbiology/ |
| 参考文献Reference |
Rapid isolation of potent SARS-CoV-2 neutralizing antibodies and protection in a small animal model,PMID:32511387,DOI:10.1101/2020.05.11.088674 |
| 录入/更新时间Date |
2021.7.20 |
| 备注Remarks |
|
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