| 中文名称Chinese name
|
SARS-CoV-2 滴鼻气管联合感染猕猴模型 |
| 编号Model number |
|
| 英文名称English name |
SARS-CoV-2 protein variant intranasal and intratraheal infected rhesus macaque model |
| 物种Species name |
猴
|
| 品系Strain name |
|
| 人类疾病Human diseases |
COVID-19 |
| 传染性Infectivity |
是 |
| 微生物Microorganism |
|
| 类别Category |
新型冠状病毒动物模型 |
| 造模因素Modeling factors |
|
| 制作方法Making method |
animals were challenged with 1.2 × 10**8 VP (1.1 × 10**4 PFU) SARS-CoV-2, administered as 1 ml by the intranasal (IN) route and 1 ml by the intratracheal (IT) route. |
| 生物学特征Biological characteristics |
|
| 医学用途Medical use |
用于新冠肺炎COVID-19致病机制研究、疫苗和药物评估。 |
| 临床表现Clinical manifestation |
|
| 病理表现Pathology |
|
| 发病天数Days of onset |
|
| 发病过程Pathogenesis process |
|
| 临床诊断Clinical diagnosis |
|
| 评价模型成功的指标Indicators for evaluating model success |
|
| 保藏单位Preservation unit |
柏斯以色列狄肯尼斯医学中心@@https://www.bidmc.org/ |
| 参考文献Reference |
DNA vaccine protection against SARS-CoV-2 in rhesus macaques,PMID:32434945,DOI:10.1093/ilar/ilv002 |
| 录入/更新时间Date |
2021.7.20 |
| 备注Remarks |
|
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