| 中文名称Chinese name
|
SARS-CoV-2 NMC2019-nCoV02 滴鼻感染雪貂模型 |
| 编号Model number |
|
| 英文名称English name |
SARS-CoV-2 NMC2019-nCoV02 intranasally infection ferret model |
| 物种Species name |
雪貂
|
| 品系Strain name |
雪貂
|
| 人类疾病Human diseases |
COVID-19 |
| 传染性Infectivity |
是 |
| 微生物Microorganism |
|
| 类别Category |
新型冠状病毒动物模型 |
| 造模因素Modeling factors |
|
| 制作方法Making method |
After 12 days of infection, all remaining ferrets, including IN infection (n = 6), DC (n = 6), and IC (n = 6), had returned to normal ranges of body temperature and body weight, and all specimenswere negative for viral RNA.infected through intranasal (IN) route with NMC2019-nCoV02 virus, an isolate of SARS-CoV-2 from a COVID-19 confirmed patient in Korea, 2020 February, at a dose of 105.5 TCID50 per ferrets. |
| 生物学特征Biological characteristics |
|
| 医学用途Medical use |
用于新冠肺炎COVID-19致病机制研究、疫苗和药物评估。 |
| 临床表现Clinical manifestation |
|
| 病理表现Pathology |
|
| 发病天数Days of onset |
|
| 发病过程Pathogenesis process |
|
| 临床诊断Clinical diagnosis |
体重下降 |
| 评价模型成功的指标Indicators for evaluating model success |
|
| 保藏单位Preservation unit |
韩国忠北大学@@https://www.cbnu.ac.kr/site/english/main.do |
| 参考文献Reference |
Infection and Rapid Transmission of SARS-CoV-2 in Ferrets.,PMID:32259477,DOI:10.1016/j.chom.2020.03.023 |
| 录入/更新时间Date |
2021.7.20 |
| 备注Remarks |
|
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