| 中文名称Chinese name
|
SARS-CoV-2 BetaCoV/Wuhan/IVDC-HB-01/2019 滴鼻感染雪貂模型 |
| 编号Model number |
|
| 英文名称English name |
SARS-CoV-2 BetaCoV/Wuhan/IVDC-HB-01/2019 intransally infection ferret model |
| 物种Species name |
雪貂
|
| 品系Strain name |
雪貂
|
| 人类疾病Human diseases |
COVID-19 |
| 传染性Infectivity |
是 |
| 微生物Microorganism |
|
| 类别Category |
新型冠状病毒动物模型 |
| 造模因素Modeling factors |
|
| 制作方法Making method |
Three- to four-month-old female ferrets (Wuxi Cay Ferret Farm, Wuxi, China) were used in this study. Groups of five ferrets were anesthetized with Zoletil 50 (Virbac, Carros, France) and inoculated intranasally with 10**5 plaque forming unit (PFU) of SARSCoV-2 CTan-H or F13-E in a volume of 1 mL and each ferret was housed in a separate cage inside an isolator (20, 22, 33, 34). |
| 生物学特征Biological characteristics |
|
| 医学用途Medical use |
用于新冠肺炎COVID-19致病机制研究、疫苗和药物评估。 |
| 临床表现Clinical manifestation |
|
| 病理表现Pathology |
|
| 发病天数Days of onset |
|
| 发病过程Pathogenesis process |
|
| 临床诊断Clinical diagnosis |
支气管炎 |
| 评价模型成功的指标Indicators for evaluating model success |
|
| 保藏单位Preservation unit |
中国农业科学院哈尔滨兽医研究所@@http://www.hvri.ac.cn |
| 参考文献Reference |
Susceptibility of ferrets, cats, dogs, and other domesticated animals to SARS–coronavirus 2,PMID:32269068,DOI:10.1126/science.abb7015 |
| 录入/更新时间Date |
2021.7.20 |
| 备注Remarks |
|
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