| 中文名称Chinese name
|
MERS‐CoV 2c EMC/2012滴鼻感染C57BL/6小鼠模型 |
| 编号Model number |
|
| 英文名称English name |
MERS‐CoV 2c EMC/2012 intranasally infection C57BL/6 mouse model |
| 物种Species name |
小鼠
|
| 品系Strain name |
C57BL/6小鼠
|
| 人类疾病Human diseases |
MERS |
| 传染性Infectivity |
是 |
| 微生物Microorganism |
|
| 类别Category |
MERS-CoV感染动物模型 |
| 造模因素Modeling factors |
|
| 制作方法Making method |
Mice were anesthetized with 1.2% tribro‐moethanol (0.2 mL/10 g of body weight, intramuscular (im)) for intranasal inoculation with 106.5 TCID50 of MERS‐CoV in the instillation group and serum‐free DMEM in the instillation control group. |
| 生物学特征Biological characteristics |
|
| 医学用途Medical use |
用于MERS致病机制研究、疫苗和药物评估。 |
| 临床表现Clinical manifestation |
|
| 病理表现Pathology |
|
| 发病天数Days of onset |
|
| 发病过程Pathogenesis process |
|
| 临床诊断Clinical diagnosis |
病毒在脑，肺中复制 |
| 评价模型成功的指标Indicators for evaluating model success |
|
| 保藏单位Preservation unit |
北京协和医学院@@http://www.cams.ac.cn/ |
| 参考文献Reference |
Genetically Engineering a Susceptible Mouse Model for MERS-CoV-Induced Acute Respiratory Distress Syndrome.,PMID:31883094,DOI:10.1007/978-1-0716-0211-9_12 |
| 录入/更新时间Date |
2021.7.20 |
| 备注Remarks |
|
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