| 中文名称Chinese name
|
MERS-CoV spike-VRP预处理滴鼻感染 MERS-15 C2 288-330+/+小鼠模型 |
| 编号Model number |
|
| 英文名称English name |
MERS-CoV 3B11 post-infection treated MERS-15 intansally infection 288-330+/+ mouse model |
| 物种Species name |
小鼠
|
| 品系Strain name |
|
| 人类疾病Human diseases |
MERS |
| 传染性Infectivity |
是 |
| 微生物Microorganism |
|
| 类别Category |
MERS-CoV感染动物模型 |
| 造模因素Modeling factors |
|
| 制作方法Making method |
To examine vaccine efficacy in the 288-330+/+/MERS-15 C2 model, mice were vaccinated with Venezuelan equine encephalitis replicon particles (VRPs) expressing MERS-CoV spike protein (spike-VRP), or mock vaccinated with VRPs that express GFP (GFP-VRP), boosted at 4 weeks post prime, and challenged with MERS-15 C2 at 4 weeks post-boost. Mice were administered a prime vaccination of 10μl by footpad injection of either spike-VRP (1×105PFU) or the control GFP-VRP (1×105PFU). Twenty-eight days later mice were boosted with the same dose of their respective VRP strain. At 28 days postboost, all vaccinated mice were challenged with 5×106PFU of MERS-15 clone 2. |
| 生物学特征Biological characteristics |
|
| 医学用途Medical use |
用于MERS致病机制研究、疫苗和药物评估。 |
| 临床表现Clinical manifestation |
|
| 病理表现Pathology |
|
| 发病天数Days of onset |
|
| 发病过程Pathogenesis process |
|
| 临床诊断Clinical diagnosis |
|
| 评价模型成功的指标Indicators for evaluating model success |
|
| 保藏单位Preservation unit |
北卡罗来纳大学教堂山分校@@https://www.unc.edu/ |
| 参考文献Reference |
A mouse model for MERS coronavirus-induced acute respiratory distress syndrome.,PMID:27892925,DOI:10.1038/nmicrobiol.2016.233 |
| 录入/更新时间Date |
2021.7.20 |
| 备注Remarks |
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