| 中文名称Chinese name
|
SARS-CoV-2 BetaCoV/wuhan/AMMS01/2020 滴鼻感染hACE2小鼠模型 |
| 编号Model number |
|
| 英文名称English name |
SARS-CoV-2 BetaCoV/wuhan/AMMS01/2020 intranasal infected hACE2 mice model |
| 物种Species name |
小鼠
|
| 品系Strain name |
|
| 人类疾病Human diseases |
COVID-19 |
| 传染性Infectivity |
是 |
| 微生物Microorganism |
|
| 类别Category |
新型冠状病毒动物模型 |
| 造模因素Modeling factors |
|
| 制作方法Making method |
For intranasal infection, wild-type C57BL/6 mice, young (4.5 weeks old) and aged (30 weeks old) hACE2 mice were anesthetized with sodium pentobarbital at a dose of 50 mg/kg though intraperitoneal route, and then intranasally infected with 4*10**5 pfu of SARSCoV-2, respectively. |
| 生物学特征Biological characteristics |
|
| 医学用途Medical use |
用于新冠肺炎COVID-19致病机制研究、疫苗和药物评估。 |
| 临床表现Clinical manifestation |
|
| 病理表现Pathology |
|
| 发病天数Days of onset |
|
| 发病过程Pathogenesis process |
|
| 临床诊断Clinical diagnosis |
体重下降 |
| 评价模型成功的指标Indicators for evaluating model success |
|
| 保藏单位Preservation unit |
中国人民解放军军事科学院军事医学研究院@@https://www.natureindex.com/institution-outputs/china/beijing-institute-of-microbiology-and-epidemiology-amms/513906ba34d6b65e6a000060 |
| 参考文献Reference |
A Mouse Model of SARS-CoV-2 Infection and Pathogenesis,PMID:32485164,DOI:10.1016/j.chom |
| 录入/更新时间Date |
2021.7.20 |
| 备注Remarks |
|
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