| 中文名称Chinese name
|
HIV-1 SIVmac251静脉途径感染印度恒河猴模型 |
| 编号Model number |
|
| 英文名称English name |
HIV-1 SIVmac251 intravenously infection of indian rhesus macaques model |
| 物种Species name |
猴
|
| 品系Strain name |
|
| 人类疾病Human diseases |
HIV |
| 传染性Infectivity |
是 |
| 微生物Microorganism |
|
| 类别Category |
HIV感染动物模型 |
| 造模因素Modeling factors |
|
| 制作方法Making method |
Twelve RMs were infected i.v. with 1,000 TCID50 of SIVmac251. Starting day 11 p.i., RMs received ART daily. After 13-14 weeks of ART, the PRI-724 treatment was initiated in the experimental group. 5 RMs received 6 cycles of PRI s.c. at 10 mg/kg/day, and 3 RMs received an uninterrupted treatment of PRI s.c. at 20 mg/kg/day for 12 weeks. The control group was maintained on ART only. |
| 生物学特征Biological characteristics |
|
| 医学用途Medical use |
用于HIV致病机制研究、疫苗和药物评估。 |
| 临床表现Clinical manifestation |
|
| 病理表现Pathology |
|
| 发病天数Days of onset |
|
| 发病过程Pathogenesis process |
|
| 临床诊断Clinical diagnosis |
|
| 评价模型成功的指标Indicators for evaluating model success |
|
| 保藏单位Preservation unit |
埃默里大学@@https://www.emory.edu/home/index.html |
| 参考文献Reference |
Pharmacological modulation of the Wnt/β-catenin pathway inhibits proliferation and promotes differentiation of long-lived memory CD4+ T-cells in ART-suppressed SIV-infected macaques.,PMID:31619550,DOI:10.1128/JVI.01094-19 |
| 录入/更新时间Date |
2021.7.20 |
| 备注Remarks |
|
当前位置：
