| 中文名称Chinese name
|
SARS-CoV-2 RNA BetaCoV/Munich/BavPat1/2020 滴鼻感染雪貂模型 |
| 编号Model number |
|
| 英文名称English name |
SARS-CoV-2 RNA BetaCoV/Munich/BavPat1/2020 nose drop infected ferret model |
| 物种Species name |
雪貂
|
| 品系Strain name |
雪貂
|
| 人类疾病Human diseases |
COVID-19 |
| 传染性Infectivity |
是 |
| 微生物Microorganism |
|
| 类别Category |
新型冠状病毒动物模型 |
| 造模因素Modeling factors |
|
| 制作方法Making method |
ferrets were inoculated intranasally with a strain of SARS-CoV-2 isolated from a German traveller returning from China. Four donor ferrets were inoculated intranasally with 6*10**5 TCID50/ml of SARS-CoV-2 virus diluted in 500μl of phosphate-buffered saline (PBS) (250 μl instilled dropwise in each nostril). The air flow rate from the donor to the recipient ferret was ~100 L min**−1and the temperature of the room was between 21 and 22 °C. |
| 生物学特征Biological characteristics |
|
| 医学用途Medical use |
用于新冠肺炎COVID-19致病机制研究、疫苗和药物评估。 |
| 临床表现Clinical manifestation |
|
| 病理表现Pathology |
|
| 发病天数Days of onset |
|
| 发病过程Pathogenesis process |
|
| 临床诊断Clinical diagnosis |
|
| 评价模型成功的指标Indicators for evaluating model success |
|
| 保藏单位Preservation unit |
鹿特丹伊拉斯姆斯大学@@https://www.erasmusmc.nl/en/research/departments/viroscience |
| 参考文献Reference |
SARS-CoV-2 is transmitted via contact and via the air between ferrets,PMID:32641684,DOI:10.1038/s41467-020-17367-2 |
| 录入/更新时间Date |
2021.7.20 |
| 备注Remarks |
|
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