| 中文名称Chinese name
|
MERS-CoV HCoV-EMC/2012 鼻内感染羊驼模型 |
| 编号Model number |
|
| 英文名称English name |
MERS-CoV HCoV-EMC/2012 intranasal infected alpaca model |
| 物种Species name |
羊驼
|
| 品系Strain name |
|
| 人类疾病Human diseases |
MERS |
| 传染性Infectivity |
是 |
| 微生物Microorganism |
|
| 类别Category |
MERS-CoV感染动物模型 |
| 造模因素Modeling factors |
|
| 制作方法Making method |
Alpacas A1–A3 were housed together and experimentally infected by intranasal instillation of 10^7 PFU of MERS-CoV diluted in sterile phosphate-buffered saline (3 mL/nare).Animals A1–A6 were held in the facility for 70 days postinfection, and all 6 animals were then reinfected intranasally with 10^7 PFU of MERS-CoV. |
| 生物学特征Biological characteristics |
|
| 医学用途Medical use |
用于MERS致病机制研究、疫苗和药物评估。 |
| 临床表现Clinical manifestation |
|
| 病理表现Pathology |
|
| 发病天数Days of onset |
|
| 发病过程Pathogenesis process |
|
| 临床诊断Clinical diagnosis |
体温体重无明显变化，无鼻腔分泌物 |
| 评价模型成功的指标Indicators for evaluating model success |
|
| 保藏单位Preservation unit |
美国科罗拉多州立大学@@https://www.colostate.edu |
| 参考文献Reference |
Infection, Replication, and Transmission of Middle East Respiratory Syndrome Coronavirus in Alpacas.,PMID:27070385,DOI:10.3201/2206.160192 |
| 录入/更新时间Date |
2021.7.20 |
| 备注Remarks |
|
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