| 中文名称Chinese name
|
SARS-CoV-2 C57BL/6 Ad5- hACE2转基因小鼠鼻内途径感染模型 |
| 编号Model number |
|
| 英文名称English name |
SARS-CoV-2 C57BL/6 Ad5- hACE2 transgenic mice intranasally infected model |
| 物种Species name |
小鼠
|
| 品系Strain name |
|
| 人类疾病Human diseases |
COVID-19 |
| 传染性Infectivity |
是 |
| 微生物Microorganism |
|
| 类别Category |
新型冠状病毒动物模型 |
| 造模因素Modeling factors |
|
| 制作方法Making method |
Mice were treated with adriamycin(ADR),a well- established chemical that induced stress and injury in the myocardium. Mice were anesthetized with isoflurane and intranasally administered with 2.5 × 10^8 Ad5- hACE2 in 50 μL DMEM. mice were intranasally infected with SARS- CoV- 2 stock virus at a dosage of 10^5 TCID50 . |
| 生物学特征Biological characteristics |
|
| 医学用途Medical use |
用于新冠肺炎COVID-19致病机制研究、疫苗和药物评估。 |
| 临床表现Clinical manifestation |
|
| 病理表现Pathology |
|
| 发病天数Days of onset |
|
| 发病过程Pathogenesis process |
|
| 临床诊断Clinical diagnosis |
|
| 评价模型成功的指标Indicators for evaluating model success |
|
| 保藏单位Preservation unit |
北京协和医院@@https://www.pumch.cn/learning.html |
| 参考文献Reference |
NA,NA,NA |
| 录入/更新时间Date |
2021.7.20 |
| 备注Remarks |
|
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