| 中文名称Chinese name
|
SARS-CoV Urbani滴鼻感染BALB/c小鼠模型 |
| 编号Model number |
|
| 英文名称English name |
SARS-CoV intranasally infection mouse model |
| 物种Species name |
小鼠
|
| 品系Strain name |
BALB/c小鼠
|
| 人类疾病Human diseases |
SARS |
| 传染性Infectivity |
是 |
| 微生物Microorganism |
|
| 类别Category |
SARS-CoV感染动物模型 |
| 造模因素Modeling factors |
|
| 制作方法Making method |
4–6-week-old female BALB/c mice (Taconic) were housed in cages with 4 mice per cage. Mice received 400 mL MAb or serum by intraperitoneal (ip) injection. The mice were bled the next day to determine the level of neutralizing antibody achieved, and lightly anesthetized mice were challenged with 10^5 TCID50 of SARS-CoV, administered intranasally. Efficacy of immunoprophylaxis in mice challenged with severe acute respiratory syndrome (SARS)–associated coronavirus (SARS-CoV). Mice (4 in each group) were treated with the indicated monoclonal antibody (MAb), at estimated doses of 40, 8, and 1.6 mg/kg, 1 day prior to intranasal challenge with 105 TCID50 of SARS-CoV. |
| 生物学特征Biological characteristics |
|
| 医学用途Medical use |
用于SARS-CoV致病机制研究、疫苗和药物评估。 |
| 临床表现Clinical manifestation |
|
| 病理表现Pathology |
|
| 发病天数Days of onset |
|
| 发病过程Pathogenesis process |
|
| 临床诊断Clinical diagnosis |
病毒在肺中复制 |
| 评价模型成功的指标Indicators for evaluating model success |
|
| 保藏单位Preservation unit |
马萨诸塞大学医学院@@https://umassmed.edu/ |
| 参考文献Reference |
Development and characterization of a severe acute respiratory syndrome-associated coronavirus-neutralizing human monoclonal antibody that provides effective immunoprophylaxis in mice.,PMID:15655773,DOI:10.1086/427242 |
| 录入/更新时间Date |
2021.7.20 |
| 备注Remarks |
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