| 中文名称Chinese name
|
SARS-CoV NS-1气管途径感染中国猕猴模型 |
| 编号Model number |
|
| 英文名称English name |
SARS-CoV NS-1 intratracheally infection of Chinese rhesus macaque model |
| 物种Species name |
猴
|
| 品系Strain name |
|
| 人类疾病Human diseases |
SARS |
| 传染性Infectivity |
是 |
| 微生物Microorganism |
|
| 类别Category |
SARS-CoV感染动物模型 |
| 造模因素Modeling factors |
|
| 制作方法Making method |
Sixteen adult Chinese rhesus macaques (No. 1–16, 8 male and 8 female, 3.5–4.5 kg, 2–4-year-old) randomly into 3 groups (8 monkeys in the immunized group, 4 monkeys in the virus control group, and 4 monkeys in the negative control group; immunized intramuscularly with 2.5 lg beta-propiolactone-inactivated whole SARS-CoV Z-1 vaccine or PBS as control, and boosted on day 7. |
| 生物学特征Biological characteristics |
|
| 医学用途Medical use |
用于SARS-CoV致病机制研究、疫苗和药物评估。 |
| 临床表现Clinical manifestation |
|
| 病理表现Pathology |
|
| 发病天数Days of onset |
|
| 发病过程Pathogenesis process |
|
| 临床诊断Clinical diagnosis |
间质性肺炎 |
| 评价模型成功的指标Indicators for evaluating model success |
|
| 保藏单位Preservation unit |
武汉大学基础医学院@@https://www.natureindex.com/institution-outputs/china/hubei-provincial-key-laboratory-of-allergy-and-immune-related-diseases-whu/58e1d819140ba0e62a8b456d |
| 参考文献Reference |
Evaluation of Antibody-Dependent Enhancement of SARS-CoV Infection in Rhesus Macaques Immunized with an Inactivated SARS-CoV Vaccine.,PMID:29541941,DOI:10.1007/s12250-018-0009-2 |
| 录入/更新时间Date |
2021.7.20 |
| 备注Remarks |
|
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