| 中文名称Chinese name
|
SARS-CoV MHV-1滴鼻感染PTX3-KO杂合子小鼠模型 |
| 编号Model number |
|
| 英文名称English name |
SARS-CoV MHV-1 intranasally infection heterozygous PTX3-KO mouse model |
| 物种Species name |
小鼠
|
| 品系Strain name |
|
| 人类疾病Human diseases |
SARS |
| 传染性Infectivity |
是 |
| 微生物Microorganism |
|
| 类别Category |
SARS-CoV感染动物模型 |
| 造模因素Modeling factors |
|
| 制作方法Making method |
PTX3-WT and -KO mice were infected with 5,000 PFU of MHV-1 intranasally. PTX3 (2 mg/kg) was administrated at 15 min intranasally post infection and repeated at 6 and 24 h intraperitoneally. |
| 生物学特征Biological characteristics |
|
| 医学用途Medical use |
用于SARS-CoV致病机制研究、疫苗和药物评估。 |
| 临床表现Clinical manifestation |
|
| 病理表现Pathology |
|
| 发病天数Days of onset |
|
| 发病过程Pathogenesis process |
|
| 临床诊断Clinical diagnosis |
|
| 评价模型成功的指标Indicators for evaluating model success |
|
| 保藏单位Preservation unit |
多伦多全科医院是大学健康网络@@https://www.uhn.ca/ |
| 参考文献Reference |
Protective effects of long pentraxin PTX3 on lung injury in a severe acute respiratory syndrome model in mice.,PMID:22732935,DOI:10.1038/labinvest.2012.92 |
| 录入/更新时间Date |
2021.7.20 |
| 备注Remarks |
|
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