| 中文名称Chinese name
|
HIV-1 pRBC腹腔途径感染HIV-Tg小鼠模型 |
| 编号Model number |
|
| 英文名称English name |
HIV-1 pRBC intraperitoneally infected of HIV-Tg mouse |
| 物种Species name |
小鼠
|
| 品系Strain name |
|
| 人类疾病Human diseases |
HIV |
| 传染性Infectivity |
是 |
| 微生物Microorganism |
|
| 类别Category |
HIV感染动物模型 |
| 造模因素Modeling factors |
|
| 制作方法Making method |
The HIV-Tg mouse line 166 was derived by pro-nuclear injection of FVB/N mouse embryos with proviral DNA encoding the entire genome of the NL4–3 molecular clone, a T cell tropic strain of HIV-1.The resulting animals contained ;20–60 copies of the proviral transgenes present at single integration sites and transmitted them in a stable Mendelian fashion. Homozygous 166 male were bred to female
C57BL/6 and (166 3 C57BL/6)F1, and the offspring were used. HIV-Tg mice (six animals per group) were treated with anti-CD154 Ab or control Ab (200 mg/mouse i.p., starting on day 0 and every 2 days thereafter), and were infected i.p. with P. chabaudi parasites on day 0. Control HIV-Tg mice(three or four animals per group) were treated with antiCD154 Ab or control Ab using the regimen described
above, but did not receive parasites. |
| 生物学特征Biological characteristics |
|
| 医学用途Medical use |
用于HIV致病机制研究、疫苗和药物评估。 |
| 临床表现Clinical manifestation |
|
| 病理表现Pathology |
|
| 发病天数Days of onset |
|
| 发病过程Pathogenesis process |
|
| 临床诊断Clinical diagnosis |
|
| 评价模型成功的指标Indicators for evaluating model success |
|
| 保藏单位Preservation unit |
美国国立卫生研究院@@https://www.nih.gov/ |
| 参考文献Reference |
In vivo CD40-CD154 (CD40 ligand) interaction induces integrated HIV expression by APC in an HIV-1-transgenic mouse model.,PMID:11207274,DOI:10.4049/jimmunol.166.5.3210 |
| 录入/更新时间Date |
2021.7.20 |
| 备注Remarks |
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