| 中文名称Chinese name
|
SARS-CoV Urbani滴鼻感染 C57BL/6J小鼠模型 |
| 编号Model number |
|
| 英文名称English name |
SARS-CoV Urbani intranasally infection C57BL/6J mouse model |
| 物种Species name |
小鼠
|
| 品系Strain name |
C57BL/6J小鼠
|
| 人类疾病Human diseases |
SARS |
| 传染性Infectivity |
是 |
| 微生物Microorganism |
|
| 类别Category |
SARS-CoV感染动物模型 |
| 造模因素Modeling factors |
|
| 制作方法Making method |
SARS-CoV in lungs of aged B6 and BALB/c mice. B6 and BALB/c mice (N= 15 per strain, aged 12–14 months) were intranasally infected with SARS-CoV (10^5 TCID50/mouse) at day 0. Five mice per strain were sacrificed at days 2, 5 and 6 post-infection. |
| 生物学特征Biological characteristics |
|
| 医学用途Medical use |
用于SARS-CoV致病机制研究、疫苗和药物评估。 |
| 临床表现Clinical manifestation |
|
| 病理表现Pathology |
|
| 发病天数Days of onset |
|
| 发病过程Pathogenesis process |
|
| 临床诊断Clinical diagnosis |
|
| 评价模型成功的指标Indicators for evaluating model success |
|
| 保藏单位Preservation unit |
美国传染病实验室@@https://www.niaid.nih.gov/research/lab-infectious-diseases |
| 参考文献Reference |
Rhesus angiotensin converting enzyme 2 supports entry of severe acute respiratory syndrome coronavirus in Chinese macaques.,PMID:18801550,DOI:10.1016/j.virol.2008.08.016 |
| 录入/更新时间Date |
2021.7.20 |
| 备注Remarks |
|
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