| 中文名称Chinese name
|
SARS-CoV MHV-A59 C57BL/6小鼠滴鼻感染模型 |
| 编号Model number |
|
| 英文名称English name |
SARS-CoV MHV-A59 C57BL/6 mice intranasally infected model |
| 物种Species name |
小鼠
|
| 品系Strain name |
C57BL/6小鼠
|
| 人类疾病Human diseases |
SARS |
| 传染性Infectivity |
是 |
| 微生物Microorganism |
|
| 类别Category |
SARS-CoV感染动物模型 |
| 造模因素Modeling factors |
|
| 制作方法Making method |
4 week-old C57BL/6 mice were anesthetized intraperitoneally (i.p.) with pentobarbital sodium combined with chloral hydrate, and then inoculated intranasally (i.n.) with 10 μL of MHV-A59 virus at 1.5×10^5. |
| 生物学特征Biological characteristics |
|
| 医学用途Medical use |
用于SARS-CoV致病机制研究、疫苗和药物评估。 |
| 临床表现Clinical manifestation |
|
| 病理表现Pathology |
|
| 发病天数Days of onset |
|
| 发病过程Pathogenesis process |
|
| 临床诊断Clinical diagnosis |
|
| 评价模型成功的指标Indicators for evaluating model success |
|
| 保藏单位Preservation unit |
中国科学院@@https://www.cas.cn |
| 参考文献Reference |
Coronavirus MHV-A59 infects the lung and causes severe pneumonia in C57BL/6 mice.,PMID:25547683,DOI:10.1007/s12250-014-3530-y |
| 录入/更新时间Date |
2021.7.20 |
| 备注Remarks |
|
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