| 中文名称Chinese name
|
SARS-CoV rSARS-CoV-MA15滴鼻感染BALB/c Ola Hsd小鼠模型 |
| 编号Model number |
|
| 英文名称English name |
SARS-CoV rSARS-CoV-MA15 intranasally infection of BALB/c Ola Hsd mouse model |
| 物种Species name |
小鼠
|
| 品系Strain name |
|
| 人类疾病Human diseases |
SARS |
| 传染性Infectivity |
是 |
| 微生物Microorganism |
|
| 类别Category |
SARS-CoV感染动物模型 |
| 造模因素Modeling factors |
|
| 制作方法Making method |
Effect of NF-ΚB inhibitors in rSARS-CoV-MA15-infected mice. Sixteenweek-old mice were intranasally infected with 100,000 PFU of rSARS-CoV-MA15 or mock infected. At 4 hpi and every 24 h from days 1 to 4, mock-infected and wild-type (wt)-infected mice were intraperitoneally injected with CAPE (wt,+C), parthenolide (wt,+P), both CAPE and parthenolide (wt,+C +P), or vehicle (wt,-). |
| 生物学特征Biological characteristics |
|
| 医学用途Medical use |
用于SARS-CoV致病机制研究、疫苗和药物评估。 |
| 临床表现Clinical manifestation |
|
| 病理表现Pathology |
|
| 发病天数Days of onset |
|
| 发病过程Pathogenesis process |
|
| 临床诊断Clinical diagnosis |
炎症浸润,肺水肿 |
| 评价模型成功的指标Indicators for evaluating model success |
|
| 保藏单位Preservation unit |
马德里自治大学@@http://www.uam.es/UAM/Home.htm?language=es |
| 参考文献Reference |
Inhibition of NF-κB-mediated inflammation in severe acute respiratory syndrome coronavirus-infected mice increases survival.,PMID:24198408,DOI:10.1128/JVI.02576-13 |
| 录入/更新时间Date |
2021.7.20 |
| 备注Remarks |
|
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