| 中文名称Chinese name
|
MERS‐CoV 2c EMC/2012气雾途径感染C57BL/6小鼠模型 |
| 编号Model number |
|
| 英文名称English name |
MERS‐CoV 2c EMC/2012 aerosolly infection C57BL/6 mouse model |
| 物种Species name |
小鼠
|
| 品系Strain name |
C57BL/6小鼠
|
| 人类疾病Human diseases |
MERS |
| 传染性Infectivity |
是 |
| 微生物Microorganism |
|
| 类别Category |
MERS-CoV感染动物模型 |
| 造模因素Modeling factors |
|
| 制作方法Making method |
MERS‐CoV virus suspensions (106.5 TCID50) and serum‐free Dulbecco's Modified Eagle Medium (DMEM) were separately added to the nebulizer reservoir to infect exposed mice in the aerosol and control aerosol groups, respectively, for 30 minutes. According to the instructions of the exposure device and mouse respiratory rate (25 mL/min per mouse), the nebulizer flow rate was set to 0.24 L/min, the diluter flow rate was set to 6.8 L/min, and the nebulizer pressure was set to 20 PSI. |
| 生物学特征Biological characteristics |
|
| 医学用途Medical use |
用于MERS致病机制研究、疫苗和药物评估。 |
| 临床表现Clinical manifestation |
|
| 病理表现Pathology |
|
| 发病天数Days of onset |
|
| 发病过程Pathogenesis process |
|
| 临床诊断Clinical diagnosis |
病毒在脑，肺中复制 |
| 评价模型成功的指标Indicators for evaluating model success |
|
| 保藏单位Preservation unit |
北京协和医学院@@http://www.cams.ac.cn/ |
| 参考文献Reference |
Genetically Engineering a Susceptible Mouse Model for MERS-CoV-Induced Acute Respiratory Distress Syndrome.,PMID:31883094,DOI:10.1007/978-1-0716-0211-9_12 |
| 录入/更新时间Date |
2021.7.20 |
| 备注Remarks |
|
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