| 中文名称Chinese name
|
SARS-CoV-2 IVCAS 6.7512 滴鼻感染hACE2小鼠模型 |
| 编号Model number |
|
| 英文名称English name |
SARS-CoV-2 IVCAS 6.7512 intranasally infection hACE2 mouse model |
| 物种Species name |
小鼠
|
| 品系Strain name |
|
| 人类疾病Human diseases |
COVID-19 |
| 传染性Infectivity |
是 |
| 微生物Microorganism |
|
| 类别Category |
新型冠状病毒动物模型 |
| 造模因素Modeling factors |
|
| 制作方法Making method |
The HFH4-hACE2 mice were intranasally infected with 3*10**4｜TCID50 virus each and sacrificed to collect tissue and blood samples at 1, 3, 5, and 7 days post-infection (DPI).Mice were anaesthetised with tribromoethanol (Avertin) (250 mg/kg) and intranasally infected with 3∗104 TCID50 (for naive infection) or 7∗105 TCID50 (for the viral challenge) SARS-CoV-2 in 50 μL DMEM per mouse. |
| 生物学特征Biological characteristics |
|
| 医学用途Medical use |
用于新冠肺炎COVID-19致病机制研究、疫苗和药物评估。 |
| 临床表现Clinical manifestation |
|
| 病理表现Pathology |
|
| 发病天数Days of onset |
|
| 发病过程Pathogenesis process |
|
| 临床诊断Clinical diagnosis |
|
| 评价模型成功的指标Indicators for evaluating model success |
|
| 保藏单位Preservation unit |
中国科学院大学@@http://job.ucas.ac.cn/ |
| 参考文献Reference |
Pathogenesis of SARS-CoV-2 in Transgenic Mice
Expressing Human Angiotensin-Converting
Enzyme 2,PMID:32516571,DOI:10.1016/j.cell.2020.05.027 |
| 录入/更新时间Date |
2021.7.20 |
| 备注Remarks |
|
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