| 中文名称Chinese name
|
SARS-CoV Toronto-2滴鼻感染雪貂模型 |
| 编号Model number |
|
| 英文名称English name |
SARS-CoV Toronto-2 intransally infection ferret model |
| 物种Species name |
雪貂
|
| 品系Strain name |
雪貂
|
| 人类疾病Human diseases |
SARS |
| 传染性Infectivity |
是 |
| 微生物Microorganism |
|
| 类别Category |
SARS-CoV感染动物模型 |
| 造模因素Modeling factors |
|
| 制作方法Making method |
Ferrets were divided randomly into four groups based upon SARS-CoV infection, mock infection, and challenge with both virus and mock inoculation. On 0 d.p.i., twentyfour ferrets (Group 1) were inoculated intranasally with serumfree medium only, and forty-two (Group 2) with SARS-CoV (103 TCID50/mL) diluted in medium. On 29 d.p.i., nine ferrets (Group 3) were inoculated with serum-free medium, and eighteen ferrets (Group 4) were challenged and inoculated with SARS-CoV (10^3 TCID50) diluted in medium. Prior to instillation of mock or virus inoculums, all ferrets were anesthetized,and 1 mL of the inoculum was administered intranasally by drop-wise delivery of 500 μL per nare. |
| 生物学特征Biological characteristics |
|
| 医学用途Medical use |
用于SARS-CoV致病机制研究、疫苗和药物评估。 |
| 临床表现Clinical manifestation |
|
| 病理表现Pathology |
|
| 发病天数Days of onset |
|
| 发病过程Pathogenesis process |
|
| 临床诊断Clinical diagnosis |
轻度支气管炎 |
| 评价模型成功的指标Indicators for evaluating model success |
|
| 保藏单位Preservation unit |
阿拉巴马大学伯明翰分校@@https://southernresearch.org/ |
| 参考文献Reference |
The SARS-CoV ferret model in an infection-challenge study.,PMID:18234270,DOI:10.1016/j.virol.2007.12.032 |
| 录入/更新时间Date |
2021.7.20 |
| 备注Remarks |
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