| 中文名称Chinese name
|
SARS-CoV PUMC-01 滴鼻感染猕猴模型 |
| 编号Model number |
|
| 英文名称English name |
SARS-CoV PUMC-01 intranasally infect rhesus macaque model |
| 物种Species name |
猴
|
| 品系Strain name |
|
| 人类疾病Human diseases |
SARS |
| 传染性Infectivity |
是 |
| 微生物Microorganism |
|
| 类别Category |
SARS-CoV感染动物模型 |
| 造模因素Modeling factors |
|
| 制作方法Making method |
Twenty rhesus monkeys belonging to five test groups were used in the study with same viral titer challenge but different drug dosing regimentsof siRNA. Four monkeys were tested in each group and necropsied at either 7 or 20 d.p.i. |
| 生物学特征Biological characteristics |
|
| 医学用途Medical use |
用于SARS-CoV致病机制研究、疫苗和药物评估。 |
| 临床表现Clinical manifestation |
|
| 病理表现Pathology |
|
| 发病天数Days of onset |
|
| 发病过程Pathogenesis process |
|
| 临床诊断Clinical diagnosis |
|
| 评价模型成功的指标Indicators for evaluating model success |
|
| 保藏单位Preservation unit |
|
| 参考文献Reference |
Application of siRNA against SARS in the rhesus macaque model.,PMID:18369784,DOI:10.1007/978-1-59745-191-8_11 |
| 录入/更新时间Date |
2021.7.20 |
| 备注Remarks |
|
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