| 中文名称Chinese name
|
SARS-CoV FFM-1滴鼻感染BALB/c小鼠模型 |
| 编号Model number |
|
| 英文名称English name |
SARS-CoV FFM-1 intranasally infection BALB/c mouse model |
| 物种Species name |
小鼠
|
| 品系Strain name |
BALB/c小鼠
|
| 人类疾病Human diseases |
SARS |
| 传染性Infectivity |
是 |
| 微生物Microorganism |
|
| 类别Category |
SARS-CoV感染动物模型 |
| 造模因素Modeling factors |
|
| 制作方法Making method |
Groups of 8 BALB/c mice were injected three times intramuscularly at 4-week interval with 2 μg of S expression plasmid DNA as indicated, or with 2 μg of pCI plasmid DNA as control. Immune sera were collected 3 weeks after the third injection and assayed for neutralizing antibodies against SARS-CoV.Eight weeks after the third DNA injection, mice were challenged intranasally with SARS-CoV (105 pfu/mouse). Booster injections were administered at 3 or 4-week intervals. |
| 生物学特征Biological characteristics |
|
| 医学用途Medical use |
用于SARS-CoV致病机制研究、疫苗和药物评估。 |
| 临床表现Clinical manifestation |
|
| 病理表现Pathology |
|
| 发病天数Days of onset |
|
| 发病过程Pathogenesis process |
|
| 临床诊断Clinical diagnosis |
|
| 评价模型成功的指标Indicators for evaluating model success |
|
| 保藏单位Preservation unit |
巴黎第七大学@@https://www.pasteur.fr/en |
| 参考文献Reference |
Heterologous viral RNA export elements improve expression of severe acute respiratory syndrome (SARS) coronavirus spike protein and protective efficacy of DNA vaccines against SARS.,PMID:17331558,DOI:10.1016/j.virol.2007.01.012 |
| 录入/更新时间Date |
2021.7.20 |
| 备注Remarks |
|
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