| 中文名称Chinese name
|
SARS-CoV-2 2019 n-CoV/USA_WA1/2020滴鼻感染 BALB/c小鼠模型 |
| 编号Model number |
|
| 英文名称English name |
SARS-CoV-2 2019 n-CoV/USA_WA1/2020 intranasally infection of BALB/c mouse model |
| 物种Species name |
小鼠
|
| 品系Strain name |
|
| 人类疾病Human diseases |
COVID-19 |
| 传染性Infectivity |
是 |
| 微生物Microorganism |
|
| 类别Category |
新型冠状病毒动物模型 |
| 造模因素Modeling factors |
|
| 制作方法Making method |
SARS-CoV-2 challenge model. BALB/c mice received aIFNAR1 mAb i.p. 24 h prior to i.n. administration of AdV-hACE2. Mice received 10 mg/kg mAb 2B04 or isotype i.p. 4 d later, followed by i.n. challenge with SARS-CoV-2 strain 2019 n-CoV/USA_WA1/2020 1 d later. |
| 生物学特征Biological characteristics |
|
| 医学用途Medical use |
用于新冠肺炎COVID-19致病机制研究、疫苗和药物评估。 |
| 临床表现Clinical manifestation |
|
| 病理表现Pathology |
|
| 发病天数Days of onset |
|
| 发病过程Pathogenesis process |
|
| 临床诊断Clinical diagnosis |
病毒在肺，脾中复制 |
| 评价模型成功的指标Indicators for evaluating model success |
|
| 保藏单位Preservation unit |
华盛顿大学医学院@@https://medicine.wustl.edu/ |
| 参考文献Reference |
Molecular determinants of severe acute respiratory syndrome coronavirus pathogenesis and virulence in young and aged mouse models of human disease.,PMID:22072787,DOI:10.1128/JVI.05957-11 |
| 录入/更新时间Date |
2021.7.20 |
| 备注Remarks |
|
当前位置：
