| 中文名称Chinese name
|
SARS-CoV-2 nCoV-WA1-2020鼻，口，眼，气管感染猕猴模型 |
| 编号Model number |
|
| 英文名称English name |
SARS-CoV-2 nCoV-WA1-2020 intranasal, oral, ocular and intratracheal infected rhesus macaque model |
| 物种Species name |
猴
|
| 品系Strain name |
|
| 人类疾病Human diseases |
COVID-19 |
| 传染性Infectivity |
是 |
| 微生物Microorganism |
|
| 类别Category |
新型冠状病毒动物模型 |
| 造模因素Modeling factors |
|
| 制作方法Making method |
Twelve animals were randomly assigned to two groups and inoculated as described previously with a total dose of 2.6x106 TCID50 of SARS-CoV-2 strain nCoV-WA1-2020 via intranasal, oral, ocular and intratracheal routes. Therapeutic treatment was initiated at 12 hours after inoculation with SARS-CoV-2 and continued once daily through 6 days post inoculation (dpi). One group of rhesus macaques was treated with a loading dose of 10mg/kg remdesivir, followed by a daily maintenance dose of 5 mg/kg. |
| 生物学特征Biological characteristics |
|
| 医学用途Medical use |
用于新冠肺炎COVID-19致病机制研究、疫苗和药物评估。 |
| 临床表现Clinical manifestation |
|
| 病理表现Pathology |
|
| 发病天数Days of onset |
|
| 发病过程Pathogenesis process |
|
| 临床诊断Clinical diagnosis |
呼吸困难 |
| 评价模型成功的指标Indicators for evaluating model success |
|
| 保藏单位Preservation unit |
美国国立卫生研究院过敏与传染病研究所病毒学实验室@@https://www.niaid.nih.gov/research/lab-virology-new |
| 参考文献Reference |
Clinical benefit of remdesivir in rhesus macaques infected with SARS-CoV-2,PMID:32516797,DOI:10.1038/s41586-020-2423-5 |
| 录入/更新时间Date |
2021.7.20 |
| 备注Remarks |
|
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