| 中文名称Chinese name
|
HIV-1静脉感染 NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ (NSG)小鼠 模型 |
| 编号Model number |
|
| 英文名称English name |
HIV HIV-1 intravenously infected NOD.Cg-Prkdcscid Il2rgtm1Wjl/SzJ (NSG) mice model |
| 物种Species name |
小鼠
|
| 品系Strain name |
|
| 人类疾病Human diseases |
HIV |
| 传染性Infectivity |
是 |
| 微生物Microorganism |
|
| 类别Category |
HIV感染动物模型 |
| 造模因素Modeling factors |
|
| 制作方法Making method |
NSG mice (8 week-old) were myeloablated by the total body irradiation at a dose of 125 cGy. 24 hr later, each mouse was implanted with a piece of human fetal thymus and liver under the kidney capsule. In addition, each mouse was injected with 5 * 10^5FL-CD34+using a 27 gauge needle via retro-orbital vein injection. BLT mice were injected with HIV-1NFNSX(200 ng of p24 Gag) via the retro-orbital vein plexus using a 27-gauge needle. |
| 生物学特征Biological characteristics |
|
| 医学用途Medical use |
用于HIV致病机制研究、疫苗和药物评估。 |
| 临床表现Clinical manifestation |
|
| 病理表现Pathology |
|
| 发病天数Days of onset |
|
| 发病过程Pathogenesis process |
|
| 临床诊断Clinical diagnosis |
|
| 评价模型成功的指标Indicators for evaluating model success |
|
| 保藏单位Preservation unit |
加州理工学院@@https://www.caltech.edu |
| 参考文献Reference |
Mechanisms of virus dissemination in bone marrow of HIV-1–infected humanized BLT mice,PMID:31657719,DOI:10.7554/eLife.46916 |
| 录入/更新时间Date |
2021.7.20 |
| 备注Remarks |
|
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