2026年10月13日 星期二

> CTLA4人源化小鼠

品系名称Strain name CTLA4人源化小鼠
编号Number
品系编号Strain number
物种 小鼠
英文名English name CTLA4 humanized mice
别名Alias name CTLA4人源化小鼠
类别Category
基因信息Gene information
描述Description
传代Generation
外观特征Appearance features
遗传特征Genetic characteristics
培育历程Cultivation
相关亚系Related substrain 无
图片Picture
生物学特征Biological characteristics
寿命与疾病Life-span and disease 肿瘤抗体治疗
应用领域Application area 肿瘤抗体治疗研究
饲养与繁殖Breeding and reproduction 近交系方式
保种单位Preserving unit 产业处,中国医学科学院医学实验动物研究所,10021,北京市朝阳区潘家园南里5号,Tel:010-67776838,Fax:010-67770683,E-mail:chanyechu@cnilas.org
数据来源Data sources
录入/更新时间Date 2021.9.15
备注Remarks  [1] Rowshanravan B, Halliday N, Sansom DM. CTLA-4: a moving target in immunotherapy[J]. Blood, 2018, 131(1): 58-67.  [2] Park J, Kwon M, Shin EC. Immune checkpoint inhibitors for cancer treatment[J]. Archives of pharmacal research, 2016, 39(11): 1577-87.  [3] Lute KD, May KF, Jr., Lu P, et al. Human CTLA4 knock-in mice unravel the quantitative link between tumor immunity and autoimmunity induced by anti-CTLA-4 antibodies[J]. Blood, 2005, 106(9): 3127-33.  [4] Ipilimumab[J]. Drugs in R&D, 2010, 10(2): 97-110.  [5] Rotte A. Combination of CTLA-4 and PD-1 blockers for treatment of cancer[J]. Journal of experimental & clinical cancer research : CR, 2019, 38(1): 255.  [6] Tremelimumab[J]. Drugs in R&D, 2010, 10(2): 123-32.  [7] Antonia S, Goldberg SB, Balmanoukian A, et al. Safety and antitumour activity of durvalumab plus tremelimumab in non-small cell lung cancer: a multicentre, phase 1b study[J]. The Lancet Oncology, 2016, 17(3): 299-308.  [8] Bahig H, Aubin F, Stagg J, et al. Phase I/II trial of Durvalumab plus Tremelimumab and stereotactic body radiotherapy for metastatic head and neck carcinoma[J]. BMC cancer, 2019, 19(1): 68.  [9] Fumet JD, Isambert N, Hervieu A, et al. Phase Ib/II trial evaluating the safety, tolerability and immunological activity of durvalumab (MEDI4736) (anti-PD-L1) plus tremelimumab (anti-CTLA-4) combined with FOLFOX in patients with metastatic colorectal cancer[J]. ESMO open, 2018, 3(4): e000375.  [10] Lee JY, Kim JW, Lim MC, et al. A phase II study of neoadjuvant chemotherapy plus durvalumab and tremelimumab in advanced-stage ovarian cancer: a Korean Gynecologic Oncology Group Study (KGOG 3046), TRU-D[J]. Journal of gynecologic oncology, 2019, 30(6): e112.  [11] He M, Chai Y, Qi J, et al. Remarkably similar CTLA-4 binding properties of therapeutic ipilimumab and tremelimumab antibodies[J]. Oncotarget, 2017, 8(40): 67129-39.
品系可用性Strain Availability
特定条款和条件Specific Term and Conditions
保存状态Strain State Legend
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