| 中文名称Chinese name
|
SARS-CoV rMA15滴鼻感染BALB/c小鼠模型 |
| 编号Model number |
|
| 英文名称English name |
SARS-CoV rMA15 intranasally infection of BALB/c mouse model |
| 物种Species name |
小鼠
|
| 品系Strain name |
BALB/c小鼠
|
| 人类疾病Human diseases |
SARS |
| 传染性Infectivity |
是 |
| 微生物Microorganism |
|
| 类别Category |
SARS-CoV感染动物模型 |
| 造模因素Modeling factors |
|
| 制作方法Making method |
Young adult mice (VRP3000 GD03-S, n=15; VRP3014 GD03-S, n=18) received their primary vaccination at 8 weeks of age and were boosted at 11 weeks of age. At 14 weeks of age, young adult mice groups were each divided in half, with one half receiving intranasal homologous challenge (105 PFU rMA15 GD03-S) and the other half receiving a heterologous challenge (10^5 PFU rMA15). |
| 生物学特征Biological characteristics |
|
| 医学用途Medical use |
用于SARS-CoV致病机制研究、疫苗和药物评估。 |
| 临床表现Clinical manifestation |
|
| 病理表现Pathology |
|
| 发病天数Days of onset |
|
| 发病过程Pathogenesis process |
|
| 临床诊断Clinical diagnosis |
|
| 评价模型成功的指标Indicators for evaluating model success |
|
| 保藏单位Preservation unit |
北卡罗来纳大学教堂山分校@@https://www.unc.edu/ |
| 参考文献Reference |
Successful vaccination strategies that protect aged mice from lethal challenge from influenza virus and heterologous severe acute respiratory syndrome coronavirus.,PMID:20980507,DOI:10.1128/JVI.01805-10 |
| 录入/更新时间Date |
2021.7.20 |
| 备注Remarks |
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