| 中文名称Chinese name
|
SARS-CoV MA15滴鼻感染EGFR小鼠模型 |
| 编号Model number |
|
| 英文名称English name |
SARS-CoV MA15 intranasally infection of EGFR mouse model |
| 物种Species name |
小鼠
|
| 品系Strain name |
|
| 人类疾病Human diseases |
SARS |
| 传染性Infectivity |
是 |
| 微生物Microorganism |
|
| 类别Category |
SARS-CoV感染动物模型 |
| 造模因素Modeling factors |
|
| 制作方法Making method |
Ten- to 12-week-old (young) and 20- to 24-week-old (old) mice were intranasally inoculated with PBS or SARS-CoV(MA15) at 10^4 or 10^5 PFU/mouse. Survival was monitored for 9 days postinfection. |
| 生物学特征Biological characteristics |
|
| 医学用途Medical use |
用于SARS-CoV致病机制研究、疫苗和药物评估。 |
| 临床表现Clinical manifestation |
|
| 病理表现Pathology |
|
| 发病天数Days of onset |
|
| 发病过程Pathogenesis process |
|
| 临床诊断Clinical diagnosis |
间质性炎症 |
| 评价模型成功的指标Indicators for evaluating model success |
|
| 保藏单位Preservation unit |
马里兰大学@@https://www.umaryland.edu/ |
| 参考文献Reference |
Overactive Epidermal Growth Factor Receptor Signaling Leads to Increased Fibrosis after Severe Acute Respiratory Syndrome Coronavirus Infection.,PMID:28404843,DOI:10.1128/JVI.00182-17 |
| 录入/更新时间Date |
2021.7.20 |
| 备注Remarks |
|
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