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> MERS-CoV MERS-CoV- Hu/Jordan-N3/2012滴鼻感染BALB/c小鼠模型
| 中文名称Chinese name | MERS-CoV MERS-CoV- Hu/Jordan-N3/2012滴鼻感染BALB/c小鼠模型 |
|---|---|
| 编号Model number | |
| 英文名称English name | MERS-CoV MERS-CoV- Hu/Jordan-N3/2012 intranasally infection BALB/c mouse model |
| 物种Species name | 小鼠 |
| 品系Strain name | BALB/c小鼠 |
| 人类疾病Human diseases | MERS |
| 传染性Infectivity | 是 |
| 微生物Microorganism | |
| 类别Category | MERS-CoV感染动物模型 |
| 造模因素Modeling factors | |
| 制作方法Making method | BALB/c mice, 8–10 weeks of age, were intramuscularly vaccinated with either PBS, 1 μg, 3μg or 10 μg MERS-CoV S nanoparticles with or without 5 μg of Matrix-M1™ adjuvant (Novavax AB, Uppsala, Sweden), which has been previously described. Mice were vaccinated at days 0 and 21.On day 30 post-initial vaccination, vaccinated mice were transduced with AdCMVhDPP4 as described previously. Mice were then intranasally inoculated with 2.5×103 pfu of MERS-CoV(Jordan). |
| 生物学特征Biological characteristics | |
| 医学用途Medical use | 用于MERS致病机制研究、疫苗和药物评估。 |
| 临床表现Clinical manifestation | |
| 病理表现Pathology | |
| 发病天数Days of onset | |
| 发病过程Pathogenesis process | |
| 临床诊断Clinical diagnosis | |
| 评价模型成功的指标Indicators for evaluating model success | |
| 保藏单位Preservation unit | 马里兰大学学院市分校@@https://www.umd.edu/ |
| 参考文献Reference | MERS-CoV spike nanoparticles protect mice from MERS-CoV infection.,PMID:28237499,DOI:10.1038/nmicrobiol.2016.287 |
| 录入/更新时间Date | 2021.7.20 |
| 备注Remarks |
