| 中文名称Chinese name
|
SARS-CoV-2 HB-01 hACE2 转基因小鼠鼻内感染模型 |
| 编号Model number |
|
| 英文名称English name |
hACE2 transgenic mice response to SARS-CoV-2 experiment wild type mouse model |
| 物种Species name |
小鼠
|
| 品系Strain name |
|
| 人类疾病Human diseases |
COVID-19 |
| 传染性Infectivity |
是 |
| 微生物Microorganism |
|
| 类别Category |
新型冠状病毒动物模型 |
| 造模因素Modeling factors |
|
| 制作方法Making method |
SARS-CoV-2 stock virus at a dosage of 10**5｜TCID50， intranasally with SARS-CoV-2 strain HB-01 at a dosage of 10**5 50% tissue culture infectious dose (TCID50) per 50 μl inoculum volume per mouse. |
| 生物学特征Biological characteristics |
|
| 医学用途Medical use |
用于新冠肺炎COVID-19致病机制研究、疫苗和药物评估。 |
| 临床表现Clinical manifestation |
|
| 病理表现Pathology |
|
| 发病天数Days of onset |
|
| 发病过程Pathogenesis process |
|
| 临床诊断Clinical diagnosis |
体重下降 |
| 评价模型成功的指标Indicators for evaluating model success |
|
| 保藏单位Preservation unit |
新兴传染病动物模型北京市重点实验室@@https://www.natureindex.com/institution-outputs/china/beijing-key-laboratory-for-animal-models-of-emerging-and-remerging-infectious-diseases-cams-pumc/5d6733732521161ac56cb464 |
| 参考文献Reference |
The pathogenicity of SARS-CoV-2 in hACE2 transgenic mice,PMID:32380511,DOI:10.1038/s41586-020-2312-y |
| 录入/更新时间Date |
2021.7.20 |
| 备注Remarks |
|
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