SARS-CoV-2 Hong Kong/VM20001061/2020滴鼻感染K18-hACE2小鼠模型

中文名称Chinese name	SARS-CoV-2 Hong Kong/VM20001061/2020滴鼻感染K18-hACE2小鼠模型
编号Model number
英文名称English name	SARS-CoV-2 Hong Kong/VM20001061/2020 intranasally infection K18-hACE2 mouse model
物种Species name	小鼠
品系Strain name
人类疾病Human diseases	COVID-19
传染性Infectivity	是
微生物Microorganism
类别Category	新型冠状病毒动物模型
造模因素Modeling factors
制作方法Making method	Five 10-week-old male Tg (K18-hACE2) 2Prlmn (Jackson Laboratories, Bar Harbor, ME) mice were challenged with 8 × 104 TCID50 in 50 μL of Hong Kong/VM20001061/2020
生物学特征Biological characteristics
医学用途Medical use	用于新冠肺炎COVID-19致病机制研究、疫苗和药物评估。
临床表现Clinical manifestation
病理表现Pathology
发病天数Days of onset
发病过程Pathogenesis process
临床诊断Clinical diagnosis	间质性炎性细胞浸润
评价模型成功的指标Indicators for evaluating model success
保藏单位Preservation unit	珍尼亚大学医学院@@https://uvahealth.com/locations/profile/university-hospital?utm_source=yext&utm_medium=GMB&y_source=1_MTY4NDQxMDEtNzE1LWxvY2F0aW9uLmdvb2dsZV93ZWJzaXRlX292ZXJyaWRl
参考文献Reference	Intranasal treatment with poly(I•C) protects aged mice from lethal respiratory virus infections.,PMID:22915814,DOI:10.1128/JVI.01410-12
录入/更新时间Date	2021.7.20
备注Remarks