| 中文名称Chinese name
|
MERS-CoV HCoV-EMC/2012滴鼻,口腔，气管，眼途径联合感染狨猴模型 |
| 编号Model number |
|
| 英文名称English name |
MERS-CoV HCoV-EMC/2012 intranasally,orally,intratracheally and ocular infection common marmoset model |
| 物种Species name |
猴
|
| 品系Strain name |
狨猴
|
| 人类疾病Human diseases |
MERS |
| 传染性Infectivity |
是 |
| 微生物Microorganism |
|
| 类别Category |
MERS-CoV感染动物模型 |
| 造模因素Modeling factors |
|
| 制作方法Making method |
CoV strain EMC/2012 was performed intranasally (100 µl per nare), orally (500 µl), intratracheally (500 µl) and ocular (50 µl per eye) with DMEM containing 4x106 TCID50 MERSCoV/ml (total dose 5.2x106 TCID50).The hyperimmune plasma and monoclonal antibody groups, consisting of one female and two male common marmosets each, received 1 ml hyperimmune plasma or m336 diluted in PBS (5 mg/ml) intravenous (I.V.) at 6 hpi, and 1 ml hyperimmune plasma or m336 subcutaneous (S.C.) at 2 dpi. |
| 生物学特征Biological characteristics |
|
| 医学用途Medical use |
用于MERS致病机制研究、疫苗和药物评估。 |
| 临床表现Clinical manifestation |
|
| 病理表现Pathology |
|
| 发病天数Days of onset |
|
| 发病过程Pathogenesis process |
|
| 临床诊断Clinical diagnosis |
|
| 评价模型成功的指标Indicators for evaluating model success |
|
| 保藏单位Preservation unit |
洛基山实验室@@https://www.niaid.nih.gov/about/rocky-mountain-laboratories |
| 参考文献Reference |
Efficacy of antibody-based therapies against Middle East respiratory syndrome coronavirus (MERS-CoV) in common marmosets,PMID:28389142,DOI:10.1038/nmicrobiol.2016.282 |
| 录入/更新时间Date |
2021.7.20 |
| 备注Remarks |
|
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