| 中文名称Chinese name
|
MERS HCoV-EMC/2012 眼睛，滴鼻，口内，气管途径感染猕猴模型 |
| 编号Model number |
|
| 英文名称English name |
MERS HCoV-EMC/2012 intranasally orally, ocularly, and intratracheally routes infected Rhesus macaques model |
| 物种Species name |
|
| 品系Strain name |
|
| 人类疾病Human diseases |
MERS |
| 传染性Infectivity |
是 |
| 微生物Microorganism |
|
| 类别Category |
MERS-CoV感染动物模型 |
| 造模因素Modeling factors |
|
| 制作方法Making method |
Another group of six rhesus macaques was treated prophylactically 24 h before MERS-CoV inoculation with 5 mg/kg remdesivir,and one group of six animals was treated therapeutically at 12 h postinoculation with MERS-CoV with 5 mg/kg remdesivir. |
| 生物学特征Biological characteristics |
|
| 医学用途Medical use |
用于MERS致病机制研究、疫苗和药物评估。 |
| 临床表现Clinical manifestation |
|
| 病理表现Pathology |
|
| 发病天数Days of onset |
|
| 发病过程Pathogenesis process |
|
| 临床诊断Clinical diagnosis |
|
| 评价模型成功的指标Indicators for evaluating model success |
|
| 保藏单位Preservation unit |
落基山实验室的机构动物护理和使用委员会@@https://www.niaid.nih.gov/research/lab-virology-new |
| 参考文献Reference |
Prophylactic and therapeutic remdesivir (GS-5734) treatment in the rhesus macaque model of MERS-CoV infection.,PMID:32054787,DOI:10.1073/pnas.1922083117 |
| 录入/更新时间Date |
2021.7.20 |
| 备注Remarks |
|
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