| 中文名称Chinese name
|
MERS-CoV EMC/2012气管途径感染狨猴模型 |
| 编号Model number |
|
| 英文名称English name |
MERS-CoV EMC/2012 intratracheally infection common marmoset model |
| 物种Species name |
猴
|
| 品系Strain name |
狨猴
|
| 人类疾病Human diseases |
MERS |
| 传染性Infectivity |
是 |
| 微生物Microorganism |
|
| 类别Category |
MERS-CoV感染动物模型 |
| 造模因素Modeling factors |
|
| 制作方法Making method |
Briefly, a total of 15 healthy male common marmosets (Callithrix jacchus; 2 years old; 230–395 g) were randomly assigned into 5 groups. For measurement of prophylactic efficacy, common marmosets (3 per group) were intraperitoneally inoculated with 5 or 20 mg/kg of purified MCA1 at 24 hours before intratracheal challenge with 5 × 106 TCID50 of MERSCoV in 500 μL of DMEM.An irrelevant human immunoglobulin G (IgG) was used as a control. |
| 生物学特征Biological characteristics |
|
| 医学用途Medical use |
用于MERS致病机制研究、疫苗和药物评估。 |
| 临床表现Clinical manifestation |
|
| 病理表现Pathology |
|
| 发病天数Days of onset |
|
| 发病过程Pathogenesis process |
|
| 临床诊断Clinical diagnosis |
病毒在肺，气管中复制，肺炎 |
| 评价模型成功的指标Indicators for evaluating model success |
|
| 保藏单位Preservation unit |
北京协和医学院@@http://www.cams.ac.cn/ |
| 参考文献Reference |
Human Neutralizing Monoclonal Antibody Inhibition of Middle East Respiratory Syndrome Coronavirus Replication in the Common Marmoset.,PMID:28472421,DOI:10.1038/nmicrobiol.2016.295 |
| 录入/更新时间Date |
2021.7.20 |
| 备注Remarks |
|
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