| 制作方法Making method |
Each study group had equal numbers of male and female animals.They were infected with HIV-1 by intraperitoneal injection of CCR5 tropic strain ADA (1.0×10^5 IU).The animals were treated with
10 mg/kg synthetic LXR agonist T0901317 (N-[4-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenyl]-N-(2,2,2-trifluoroethyl)benzenesulfonamide, purchased from Sigma-Aldrich, St. Louis, MO) administered intraperitoneally every second day. A group of control humanized (hu)-mice (n 5 4) received only the solvent [15% Cremophor/phosphatebuffered saline (PBS); Sigma-Aldrich] without the T0901317. Two treatment regimens were tested. In the first group (n 5 8), treatment was initiated 1 week before the infection and stopped on the day of infection. In the second group (n 5 8), we started treating mice 2 weeks after infection and continued treatment of 6 weeks. |
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