| 中文名称Chinese name
|
SARS-CoV-2 BetaCoV/Wuhan/IVDC-HB-01/2020|EPI_ISL_402119滴鼻感染野生ICR小鼠模型感染 |
| 编号Model number |
|
| 英文名称English name |
SARS-CoV-2 BetaCoV/Wuhan/IVDC-HB-01/2020|EPI_ISL_402119 intranasally infection WT ICR mouse model |
| 物种Species name |
小鼠
|
| 品系Strain name |
|
| 人类疾病Human diseases |
COVID-19 |
| 传染性Infectivity |
是 |
| 微生物Microorganism |
|
| 类别Category |
新型冠状病毒动物模型 |
| 造模因素Modeling factors |
|
| 制作方法Making method |
Mice were inoculated intranasally with SARS-CoV-2 stock virus (HB-01) at a dosage of 10^5 TCID50/50 μl inoculum volume per mouse after the mice were anesthetized by 2.5% avertin, and the mock-treated hACE2 mice(ACE2-Mock) were used as control. |
| 生物学特征Biological characteristics |
|
| 医学用途Medical use |
用于新冠肺炎COVID-19致病机制研究、疫苗和药物评估。 |
| 临床表现Clinical manifestation |
|
| 病理表现Pathology |
|
| 发病天数Days of onset |
|
| 发病过程Pathogenesis process |
|
| 临床诊断Clinical diagnosis |
|
| 评价模型成功的指标Indicators for evaluating model success |
|
| 保藏单位Preservation unit |
中国医学科学院 医学实验动物研究所 新发再发传染病动物模型研究北京市重点实验室@@https://www.natureindex.com/institution-outputs/china/beijing-key-laboratory-for-animal-models-of-emerging-and-remerging-infectious-diseases-cams-pumc/5d6733732521161ac56cb464 |
| 参考文献Reference |
The Pathogenicity of SARS-CoV-1 2 in hACE2 Transgenic Mice,NA,NA |
| 录入/更新时间Date |
2021.7.20 |
| 备注Remarks |
|
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