| 中文名称Chinese name
|
MERS-CoV HCoV-EMC/2012滴鼻感染狨猴模型 |
| 编号Model number |
|
| 英文名称English name |
MERS-CoV HCoV-EMC/2012 intransally infection of common marmoset model |
| 物种Species name |
猴
|
| 品系Strain name |
狨猴
|
| 人类疾病Human diseases |
MERS |
| 传染性Infectivity |
是 |
| 微生物Microorganism |
|
| 类别Category |
MERS-CoV感染动物模型 |
| 造模因素Modeling factors |
|
| 制作方法Making method |
Inoculation with MERS-CoV strain EMC/2012 was performed intranasally (100 µl per nare), orally (500 µl), intratracheally (500 µl) and ocular (50 µl per eye) with DMEM containing 4x10^6 TCID50/ml (total dose 5.2x10^6 TCID50).The marmosets in group II were treated prophylactically on day -1 with 25mg/kg REGN3051. |
| 生物学特征Biological characteristics |
|
| 医学用途Medical use |
用于MERS致病机制研究、疫苗和药物评估。 |
| 临床表现Clinical manifestation |
|
| 病理表现Pathology |
|
| 发病天数Days of onset |
|
| 发病过程Pathogenesis process |
|
| 临床诊断Clinical diagnosis |
体重下降 |
| 评价模型成功的指标Indicators for evaluating model success |
|
| 保藏单位Preservation unit |
国立卫生研究院@@https://www.nih.gov/ |
| 参考文献Reference |
Prophylactic and therapeutic efficacy of mAb treatment against MERS-CoV in common marmosets.,PMID:29885377,DOI:10.1038/nmicrobiol.2016.284 |
| 录入/更新时间Date |
2021.7.20 |
| 备注Remarks |
|
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