| 中文名称Chinese name
|
HIV CCR5-tropic静脉途径感染人源化BLT小鼠模型 |
| 编号Model number |
|
| 英文名称English name |
HIV CCR5-tropic intravenously infected of humanized BLT mouse model |
| 物种Species name |
小鼠
|
| 品系Strain name |
|
| 人类疾病Human diseases |
HIV |
| 传染性Infectivity |
是 |
| 微生物Microorganism |
|
| 类别Category |
HIV感染动物模型 |
| 造模因素Modeling factors |
|
| 制作方法Making method |
Briefly, preconditioned NOD/SCID-gamma chain null (NSG) mice (The Jackson Laboratories) implanted with thymus and liver tissue (Advanced Bioscience Resources) were transplanted with 2×10^5 to 3×10^5 autologous human fetal liver CD34+ cells and monitored for human engraftment.Humanized BLT mice are susceptible to vaginal, rectal, and intravenous HIV infection (10– 12, 36). We infected BLT mice with CCR5-tropic HIV (JR-CSF or SF162). Infected BLT mice received ART consisting of daily intraperitoneal injections of emtricitabine (FTC; 140 to 200 mg/kg body weight), tenofovir disoproxil fumarate (TDF; 146 to 208 mg/kg), and raltegravir (RAL; 56 to 80 mg/kg). BLT mouse that received ART for 58 days (followed for a total of 77 days postexposure) as well as in a pair of untreated, infected BLT mice (followed for a total of 69 and 70 days postexposure) |
| 生物学特征Biological characteristics |
|
| 医学用途Medical use |
用于HIV致病机制研究、疫苗和药物评估。 |
| 临床表现Clinical manifestation |
|
| 病理表现Pathology |
|
| 发病天数Days of onset |
|
| 发病过程Pathogenesis process |
|
| 临床诊断Clinical diagnosis |
血浆病毒血症 |
| 评价模型成功的指标Indicators for evaluating model success |
|
| 保藏单位Preservation unit |
北卡罗来纳大学教堂山分校@@https://www.unc.edu/ |
| 参考文献Reference |
Generation of HIV latency in humanized BLT mice.,PMID:22013053,DOI:10.1128/JVI.06120-11 |
| 录入/更新时间Date |
2021.7.20 |
| 备注Remarks |
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