| 中文名称Chinese name
|
influenza A/teal/Egypt/12908-NAMRU3/2005滴鼻感染雪貂模型 |
| 编号Model number |
|
| 英文名称English name |
influenza A/teal/Egypt/12908-NAMRU3/2005 infection ferret model |
| 物种Species name |
雪貂
|
| 品系Strain name |
雪貂
|
| 人类疾病Human diseases |
influenza |
| 传染性Infectivity |
是 |
| 微生物Microorganism |
|
| 类别Category |
流感感染动物模型 |
| 造模因素Modeling factors |
|
| 制作方法Making method |
Adult male Fitch ferrets (4 to 5 months of age, Triple F Farms, Sayre, PA) were used. One group of four animals was inoculated three times (weeks 0, 4 and 22) intramuscularly (i.m.) with H10 VLPs (30 μg of total HA).Ferrets were anesthetized with an i.m. injection of a ketamine-xylazine-atropine cocktail and challenged on week 27 i. n. with 10^6 EID50 of influenza A/teal/Egypt/12908-NAMRU3/2005 (H10N1) virus in a total volume of 1 ml (500 μl per nostril) diluted in PBS. Viral challenge took place at week 27, five weeks after the final vaccination. |
| 生物学特征Biological characteristics |
|
| 医学用途Medical use |
用于流感致病机制研究、疫苗和药物评估。 |
| 临床表现Clinical manifestation |
|
| 病理表现Pathology |
|
| 发病天数Days of onset |
|
| 发病过程Pathogenesis process |
|
| 临床诊断Clinical diagnosis |
|
| 评价模型成功的指标Indicators for evaluating model success |
|
| 保藏单位Preservation unit |
美国疾病控制与预防中心@@https://www.cdc.gov/genomics/about/contact.htm |
| 参考文献Reference |
Mono- and quadri-subtype virus-like particles (VLPs) containing H10 subtype elicit protective immunity to H10 influenza in a ferret challenge model.,PMID:27663671,DOI:10.1038/nmicrobiol.2016.263 |
| 录入/更新时间Date |
2021.7.20 |
| 备注Remarks |
|
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