| 中文名称Chinese name
|
MERS-CoV EMC/2012滴鼻感染RAG1-/-小鼠模型 |
| 编号Model number |
|
| 英文名称English name |
MERS-CoV EMC/2012 intranasally RAG1-/- mouse model |
| 物种Species name |
小鼠
|
| 品系Strain name |
|
| 人类疾病Human diseases |
MERS |
| 传染性Infectivity |
是 |
| 微生物Microorganism |
|
| 类别Category |
MERS-CoV感染动物模型 |
| 造模因素Modeling factors |
|
| 制作方法Making method |
Intranasally treated with 2000 U of IFN-β, 200 µg of HR2P-M2, both IFN-β (2000 U) and HR2P-M2 (200 µg), or phosphatebuffered saline (PBS) only, as described in “Materials and Methods” section. Six hours later, mice were infected with 1 × 105 plaque-forming units (PFUs) of MERS-CoV in a total volume of 50 µL of Dulbecco’s modified Eagle medium (DMEM). |
| 生物学特征Biological characteristics |
|
| 医学用途Medical use |
用于MERS致病机制研究、疫苗和药物评估。 |
| 临床表现Clinical manifestation |
|
| 病理表现Pathology |
|
| 发病天数Days of onset |
|
| 发病过程Pathogenesis process |
|
| 临床诊断Clinical diagnosis |
|
| 评价模型成功的指标Indicators for evaluating model success |
|
| 保藏单位Preservation unit |
爱荷华大学@@https://uiowa.edu/ |
| 参考文献Reference |
Protective Effect of Intranasal Regimens Containing Peptidic Middle East Respiratory Syndrome Coronavirus Fusion Inhibitor Against MERS-CoV Infection.,PMID:26164863,DOI:10.1093/infdis/jiv325 |
| 录入/更新时间Date |
2021.7.20 |
| 备注Remarks |
|
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